Dithranol is a most commonly used in treatment of psoriasis due to its various effects such as keratolytic, anti-eczema, antifungal properties. It is used along with salicylic acid for prevention of its oxidation. The keratolytic property of the dithranol makes it popular in the treatment of psoriasis, but during long term use patients reported some side effects like burning sensation, inflammation, irritation and hyper-pigmentation. No other drugs are more effective as compare to dithranol. In addition, dithranol is used along with other drugs like betamethasone, hydroquinone and lignocaine to improve its effects and decrease its side effects. Our study reveals the compatibility of some drugs used in dermatological problems. These drugs uniformly mixed together in various proportions and kept the samples in different temperature conditions for 21 days. After completion of specified period the samples were evaluated physically follow by physical appearance, color, state and stability was also evaluated by thermal analysis using DSC for finding physical constant of samples. Moreover, chemical stability and compatibility were evaluated through FTIR. There were no changes observed in the results of drugs basics physical evaluation. No changed observed in their physical constant also there were no changed observed in chemical structural properties of drugs. The study concludes that the drugs used in the study were compatible with each other.
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